Reaction Details | |||
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Target | Glucocorticoid receptor | ||
Ligand | BDBM50402482 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
Ki | 21±n/a nM | ||
Citation | Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glucocorticoid receptor | |||
Name: | Glucocorticoid receptor | ||
Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 85656.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P04150 | ||
Residue: | 777 | ||
Sequence: |
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BDBM50402482 | |||
n/a | |||
Name | BDBM50402482 | ||
Synonyms: | CHEMBL2204059 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H25N3O2 | ||
Mol. Mass. | 375.4635 | ||
SMILES | Cc1ccnc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c1 |r,wU:15.15,18.22,(31.62,-37.88,;30.28,-38.65,;28.94,-37.86,;27.59,-38.62,;27.59,-40.16,;28.92,-40.95,;28.92,-42.51,;27.59,-43.29,;27.59,-44.85,;26.24,-45.62,;24.91,-44.85,;23.56,-45.64,;24.91,-43.3,;26.26,-42.53,;26.26,-40.99,;28.9,-45.62,;28.9,-47.16,;30.21,-47.93,;31.55,-47.17,;31.55,-45.63,;30.23,-44.85,;32.88,-47.95,;34.21,-47.19,;35.53,-47.96,;35.53,-49.51,;34.19,-50.27,;32.88,-49.49,;30.28,-40.19,)| | ||
Structure |