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TargetGlucocorticoid receptor
LigandBDBM50402483
Substrate/Competitorn/a
Meas. Tech.ChEMBL_886648 (CHEMBL2216233)
Ki 47±n/a nM
Citation Hunt, HJRay, NCHynd, GSutton, JSajad, MO'Connor, EAhmed, SLockey, PDaly, SBuckley, GClark, RDRoe, RBlasey, CBelanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucocorticoid receptor
Name:Glucocorticoid receptor
Synonyms:GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:Enzyme
Mol. Mass.:85656.87
Organism:Homo sapiens (Human)
Description:P04150
Residue:777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
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  Blast E-value cutoff:
BDBM50402483
n/a
NameBDBM50402483
Synonyms:CHEMBL2204058
TypeSmall organic molecule
Emp. Form.C23H22F3N3O2
Mol. Mass.429.4349
SMILESFC(F)(F)c1cccc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)n1 |r,wU:18.18,21.25,(8.34,-35.49,;8.33,-37.03,;6.99,-37.8,;6.98,-36.26,;9.66,-37.81,;11.01,-37.05,;12.35,-37.84,;12.35,-39.38,;10.99,-40.13,;10.99,-41.7,;9.65,-42.48,;9.65,-44.03,;8.31,-44.8,;6.98,-44.04,;5.63,-44.83,;6.98,-42.49,;8.33,-41.71,;8.33,-40.17,;10.97,-44.81,;10.97,-46.35,;12.28,-47.12,;13.62,-46.36,;13.62,-44.82,;12.3,-44.04,;14.95,-47.14,;16.28,-46.38,;17.6,-47.15,;17.6,-48.7,;16.26,-49.46,;14.95,-48.68,;9.66,-39.35,)|
Structure
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