Reaction Details | |||
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Target | Glucocorticoid receptor | ||
Ligand | BDBM50402484 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
Ki | 22±n/a nM | ||
Citation | Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glucocorticoid receptor | |||
Name: | Glucocorticoid receptor | ||
Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 85656.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P04150 | ||
Residue: | 777 | ||
Sequence: |
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BDBM50402484 | |||
n/a | |||
Name | BDBM50402484 | ||
Synonyms: | CHEMBL2204057 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H25N3O2 | ||
Mol. Mass. | 375.4635 | ||
SMILES | Cc1cccc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)n1 |r,wU:15.15,18.22,(58.07,-19.9,;59.4,-20.68,;60.75,-19.92,;62.09,-20.7,;62.09,-22.24,;60.73,-23,;60.73,-24.56,;59.4,-25.35,;59.4,-26.9,;58.06,-27.67,;56.72,-26.9,;55.37,-27.69,;56.72,-25.35,;58.07,-24.58,;58.07,-23.04,;60.72,-27.67,;60.72,-29.21,;62.02,-29.99,;63.36,-29.23,;63.36,-27.68,;62.04,-26.9,;64.69,-30.01,;66.02,-29.24,;67.34,-30.02,;67.34,-31.56,;66,-32.32,;64.69,-31.54,;59.4,-22.22,)| | ||
Structure |