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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402495 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 8±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50402495 | |||
| n/a | |||
| Name | BDBM50402495 | ||
| Synonyms: | CHEMBL2204046 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22Cl2N2O2 | ||
| Mol. Mass. | 429.339 | ||
| SMILES | Clc1ccc(Cl)c(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c1 |r,wU:16.16,19.23,(23.01,-44.53,;24.34,-45.3,;25.69,-44.54,;27.03,-45.33,;27.03,-46.87,;28.36,-47.65,;25.67,-47.63,;25.67,-49.19,;24.34,-49.97,;24.34,-51.52,;23,-52.29,;21.67,-51.53,;20.31,-52.32,;21.67,-49.98,;23.01,-49.21,;23.01,-47.67,;25.66,-52.3,;25.66,-53.84,;26.96,-54.61,;28.3,-53.85,;28.3,-52.31,;26.98,-51.53,;29.63,-54.63,;30.96,-53.87,;32.28,-54.64,;32.28,-56.19,;30.94,-56.95,;29.63,-56.17,;24.34,-46.84,)| | ||
| Structure | 
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