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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402499 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 7±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50402499 | |||
| n/a | |||
| Name | BDBM50402499 | ||
| Synonyms: | CHEMBL2204042 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23ClN2O2 | ||
| Mol. Mass. | 394.894 | ||
| SMILES | Clc1ccccc1Cc1c([nH]c(=O)[nH]c1=O)[C@@H]1CC[C@@H](CC1)c1ccccc1 |r,wU:16.17,19.24,(27.25,-29.65,;25.92,-28.87,;25.92,-27.33,;24.58,-26.54,;23.23,-27.3,;23.23,-28.84,;24.56,-29.63,;24.56,-31.19,;23.23,-31.97,;23.23,-33.53,;21.89,-34.29,;20.55,-33.53,;19.2,-34.32,;20.55,-31.98,;21.9,-31.21,;21.9,-29.67,;24.54,-34.3,;24.54,-35.84,;25.85,-36.61,;27.19,-35.85,;27.19,-34.31,;25.87,-33.53,;28.52,-36.63,;29.85,-35.87,;31.17,-36.64,;31.17,-38.19,;29.83,-38.95,;28.52,-38.17,)| | ||
| Structure | 
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