Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402500 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886648 (CHEMBL2216233) | ||
| Ki | 78±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50402500 | |||
| n/a | |||
| Name | BDBM50402500 | ||
| Synonyms: | CHEMBL2204041 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H28N2O2 | ||
| Mol. Mass. | 388.502 | ||
| SMILES | CCc1ccccc1Cc1c([nH]c(=O)[nH]c1=O)[C@@H]1CC[C@@H](CC1)c1ccccc1 |r,wU:17.18,20.25,(11.27,-28.43,;9.93,-29.19,;8.61,-28.41,;8.61,-26.86,;7.26,-26.08,;5.92,-26.84,;5.92,-28.38,;7.24,-29.16,;7.24,-30.72,;5.91,-31.51,;5.91,-33.06,;4.57,-33.83,;3.24,-33.06,;1.89,-33.85,;3.24,-31.51,;4.59,-30.74,;4.59,-29.2,;7.23,-33.83,;7.23,-35.37,;8.54,-36.15,;9.88,-35.39,;9.88,-33.85,;8.55,-33.06,;11.2,-36.17,;12.53,-35.4,;13.85,-36.18,;13.85,-37.72,;12.51,-38.48,;11.2,-37.7,)| | ||
| Structure | 
| ||