| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dopamine beta-hydroxylase |
|---|
| Ligand | BDBM50025788 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_59425 |
|---|
| IC50 | 95499±n/a nM |
|---|
| Citation |  Burke, BJ; Hopfinger, AJ 1-(substituted-benzyl)imidazole-2(3H)-thione inhibitors of dopamine beta-hydroxylase. J Med Chem33:274-81 (1990) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dopamine beta-hydroxylase |
|---|
| Name: | Dopamine beta-hydroxylase |
|---|
| Synonyms: | DOPO_RAT | Dbh |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69869.10 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_59425 |
|---|
| Residue: | 620 |
|---|
| Sequence: | MQPHLSHQPCWSLPSPSVREAASMYGTAVAIFLVILVAALQGSEPPESPFPYHIPLDPEG
TLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYFADAWS
DQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPF
QSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITEL
PLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNESEAFPMFNGPCDSKMKPDRLNYCRH
VLAAWALGAKAFYYPEEAGVPLGSSGSSRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASL
RPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHTHLTG
RKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMAT
VGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQ
QFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPNITSAVEEPDPRCP
IRQTRGPAGPFVVITHGGRH
|
|
|
|---|
| BDBM50025788 |
|---|
| n/a |
|---|
| Name | BDBM50025788 |
|---|
| Synonyms: | 1-(4-Chloro-benzyl)-1,3-dihydro-imidazole-2-thione | CHEMBL306643 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H9ClN2S |
|---|
| Mol. Mass. | 224.71 |
|---|
| SMILES | Clc1ccc(Cn2cc[nH]c2=S)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
