Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50291754 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_21101 (CHEMBL633695) |
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Ki | 5.012E3±n/a nM |
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KOFF | 7.762E-5 s-1 |
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KON | 1.514E1 M-1s-1 |
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Citation | Krantz, A; Spencer, RW; Tam, TF; Liak, TJ; Copp, LJ; Thomas, EM; Rafferty, SP Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase. J Med Chem33:464-79 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50291754 |
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n/a |
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Name | BDBM50291754 |
Synonyms: | 2-Amino-5-ethyl-benzo[d][1,3]oxazin-4-one | CHEMBL146219 |
Type | Small organic molecule |
Emp. Form. | C10H10N2O2 |
Mol. Mass. | 190.1986 |
SMILES | CCc1cccc2nc(N)oc(=O)c12 |
Structure |
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