| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50131441 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_85812 (CHEMBL878439) |
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| IC50 | 1.58±n/a nM |
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| Citation |  ter Laak, AM; Venhorst, J; Donné-Op den Kelder, GM; Timmerman, H The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem38:3351-60 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50131441 |
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| n/a |
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| Name | BDBM50131441 |
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| Synonyms: | 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine | CHEMBL1106 | EPINASTINE | Elestat | Flurinol | WAL 80 | WAL 801 | epinastine hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N3 |
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| Mol. Mass. | 249.3104 |
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| SMILES | NC1=NCC2N1c1ccccc1Cc1ccccc21 |t:1| |
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| Structure | 
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