| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM85139 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48120 (CHEMBL661439) |
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| IC50 | 178±n/a nM |
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| Citation |  Henke, BR; Willson, TM; Sugg, EE; Croom, DK; Dougherty, RW; Queen, KL; Birkemo, LS; Ervin, GN; Grizzle, MK; Johnson, MF; James, MK 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents. J Med Chem39:2655-8 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM85139 |
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| n/a |
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| Name | BDBM85139 |
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| Synonyms: | CCK-A Agonist 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H31N5O3 |
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| Mol. Mass. | 557.6416 |
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| SMILES | CC(C)N(C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)c1ccccc1 |
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| Structure | 
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