| Reaction Details |
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 | Report a problem with these data |
| Target | Histidine-rich protein PFHRP-II |
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| Ligand | BDBM50123575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_215891 (CHEMBL820823) |
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| IC50 | 27.1±n/a nM |
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| Citation |  Ryckebusch, A; Deprez-Poulain, R; Maes, L; Debreu-Fontaine, MA; Mouray, E; Grellier, P; Sergheraert, C Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives. J Med Chem46:542-57 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histidine-rich protein PFHRP-II |
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| Name: | Histidine-rich protein PFHRP-II |
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| Synonyms: | HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35156.49 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_500704 |
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| Residue: | 332 |
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| Sequence: | MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHA
HHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHA
ADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYA
HHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHA
ADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAH
HATDAHHAAAHHATDAHHAAAHHEAATHCLRH
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| BDBM50123575 |
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| n/a |
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| Name | BDBM50123575 |
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| Synonyms: | (3-{4-[3-(Bis-cyclopropylmethyl-amino)-propyl]-piperazin-1-yl}-propyl)-(7-chloro-quinolin-4-yl)-amine | CHEMBL153507 | N-(3-(4-(3-(bis(cyclopropylmethyl)amino)propyl)piperazin-1-yl)propyl)-7-chloroquinolin-4-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C27H40ClN5 |
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| Mol. Mass. | 470.093 |
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| SMILES | Clc1ccc2c(NCCCN3CCN(CCCN(CC4CC4)CC4CC4)CC3)ccnc2c1 |
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| Structure | 
|
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