Reaction Details | |||
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Target | ATP-dependent translocase ABCB1 | ||
Ligand | BDBM50410913 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_357500 (CHEMBL866963) | ||
IC50 | 4230±n/a nM | ||
Citation | Bisi, A; Gobbi, S; Rampa, A; Belluti, F; Piazzi, L; Valenti, P; Gyemant, N; Molnár, J New potent P-glycoprotein inhibitors carrying a polycyclic scaffold. J Med Chem49:3049-51 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
ATP-dependent translocase ABCB1 | |||
Name: | ATP-dependent translocase ABCB1 | ||
Synonyms: | ABCB1 | MDR1 | MDR1_HUMAN | Multidrug Resistance Transporter MDR 1 | Multidrug resistance protein 1 | Multidrug resistance protein 1/Multidrug resistance associated protein 1 | P-glycoprotein (P-gp) | P-glycoprotein 1 | PGY1 | ||
Type: | Protein | ||
Mol. Mass.: | 141503.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08183 | ||
Residue: | 1280 | ||
Sequence: |
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BDBM50410913 | |||
n/a | |||
Name | BDBM50410913 | ||
Synonyms: | CHEMBL209128 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H32N2O4 | ||
Mol. Mass. | 496.5968 | ||
SMILES | COc1ccc(CCN(C)CCN2C(=O)C3C(C4c5ccccc5C3c3ccccc43)C2=O)cc1OC |TLB:19:18:30.25:16.15,29:30:23.18:16.15,THB:13:15:23.18:30.25,22:23:30.25:16.15,31:16:23.18:30.25,(8.02,-24.19,;8.37,-22.92,;7.45,-21.98,;6.17,-22.31,;5.26,-21.37,;5.62,-20.11,;4.7,-19.17,;3.42,-19.49,;2.5,-18.55,;2.86,-17.28,;1.23,-18.88,;.31,-17.93,;-.96,-18.26,;-1.45,-19.48,;-.19,-19.14,;-2.76,-19.4,;-3.09,-18.12,;-3.4,-19.91,;-5.11,-20.41,;-6.44,-19.64,;-7.77,-20.41,;-7.77,-21.96,;-6.44,-22.73,;-5.09,-21.95,;-3.31,-21.45,;-1.9,-22.34,;-.5,-23.03,;.81,-22.16,;.7,-20.59,;-.71,-19.9,;-2.01,-20.77,;-1.98,-17.42,;-1.89,-16.11,;6.88,-19.77,;7.8,-20.71,;9.08,-20.38,;10.01,-21.32,)| | ||
Structure |