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TargetAmine oxidase [flavin-containing] B
LigandBDBM50282510
Substrate/Competitorn/a
Meas. Tech.ChEMBL_417162 (CHEMBL909463)
IC50 2.57±n/a nM
Citation Novaroli, L; Daina, A; Favre, E; Bravo, J; Carotti, A; Leonetti, F; Catto, M; Carrupt, PA; Reist, M Impact of species-dependent differences on screening, design, and development of MAO B inhibitors. J Med Chem49:6264-72 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Amine oxidase [flavin-containing] B
Name:Amine oxidase [flavin-containing] B
Synonyms:AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:Enzyme
Mol. Mass.:58469.65
Organism:Rattus norvegicus (rat)
Description:P19643
Residue:520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50282510
n/a
NameBDBM50282510
Synonyms:7-(4-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one | 7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-one | CHEMBL274030
TypeSmall organic molecule
Emp. Form.C18H15ClO3
Mol. Mass.314.763
SMILESCc1c(C)c(=O)oc2cc(OCc3ccc(Cl)cc3)ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: