| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 8 |
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| Ligand | BDBM50414968 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_465785 (CHEMBL948147) |
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| IC50 | 28±n/a nM |
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| Citation |  Shamovsky, I; Connolly, S; David, L; Ivanova, S; Nordén, B; Springthorpe, B; Urbahns, K Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships. J Med Chem51:1162-78 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 8 |
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| Name: | C-C chemokine receptor type 8 |
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| Synonyms: | CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40855.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_454278 |
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| Residue: | 355 |
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| Sequence: | MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL
VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS
MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV
LQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLV
LIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY
AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
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| BDBM50414968 |
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| n/a |
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| Name | BDBM50414968 |
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| Synonyms: | CHEMBL410885 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N4O2 |
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| Mol. Mass. | 442.5527 |
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| SMILES | O=C(N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1)c1ccncn1 |
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| Structure | 
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