| Reaction Details |
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 | Report a problem with these data |
| Target | 7-dehydrocholesterol reductase |
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| Ligand | BDBM50412077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_550766 (CHEMBL1008660) |
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| IC50 | 600±n/a nM |
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| Citation |  Chang, LC; Bhat, KP; Pisha, E; Kennelly, EJ; Fong, HH; Pezzuto, JM; Kinghorn, AD Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J Nat Prod61:1257-62 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 7-dehydrocholesterol reductase |
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| Name: | 7-dehydrocholesterol reductase |
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| Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54508.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864350 |
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| Residue: | 475 |
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| Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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| BDBM50412077 |
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| n/a |
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| Name | BDBM50412077 |
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| Synonyms: | (+)-PACHYSAMINE B |
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| Type | Small organic molecule |
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| Emp. Form. | C29H50N2O |
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| Mol. Mass. | 442.7201 |
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| SMILES | [#6]-[#6@@H](-[#6@H]1-[#6]-[#6]-[#6@H]2-[#6@@H]-3-[#6]-[#6]-[#6@H]4-[#6]-[#6@@H](-[#6]-[#6][C@]4([#6])[#6@H]-3-[#6]-[#6][C@]12[#6])-[#7](-[#6])-[#6](=O)\[#6]=[#6](\[#6])-[#6])-[#7](-[#6])-[#6] |r| |
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| Structure | 
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