| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 7-dehydrocholesterol reductase |
|---|
| Ligand | BDBM50412080 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_550766 (CHEMBL1008660) |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Chang, LC; Bhat, KP; Pisha, E; Kennelly, EJ; Fong, HH; Pezzuto, JM; Kinghorn, AD Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J Nat Prod61:1257-62 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 7-dehydrocholesterol reductase |
|---|
| Name: | 7-dehydrocholesterol reductase |
|---|
| Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 54508.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_864350 |
|---|
| Residue: | 475 |
|---|
| Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
|
|
|
|---|
| BDBM50412080 |
|---|
| n/a |
|---|
| Name | BDBM50412080 |
|---|
| Synonyms: | CHEMBL342394 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H41NO |
|---|
| Mol. Mass. | 359.5884 |
|---|
| SMILES | CO[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1)[C@H](C)N(C)C |r,c:20| |
|---|
| Structure | 
|
|---|
Search and Browse
