| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Ligand | BDBM50201073 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_558727 (CHEMBL954129) |
|---|
| EC50 | 128.82±n/a nM |
|---|
| Citation |  Ye, M; Dawson, MI 3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA). Bioorg Med Chem Lett19:127-31 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Synonyms: | ACHA4_HUMAN | CHRNA4 | CHRNA4 protein | NACRA4 | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Nicotinic acetylcholine receptor alpha4/beta2/alpha5 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 69963.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | NACHRA4 |
|---|
| Residue: | 627 |
|---|
| Sequence: | MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD
VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR
PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG
SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR
RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS
LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR
PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP
SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG
GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV
SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR
IFLWMFIIVCLLGTVGLFLPPWLAGMI
|
|
|
|---|
| BDBM50201073 |
|---|
| n/a |
|---|
| Name | BDBM50201073 |
|---|
| Synonyms: | (1R,6S)-3-(5-methoxy-pyridin-3-yl)-3,8-diaza-bicyclo[4.2.0]octane | (1R,6S)-3-(5-methoxypyridin-3-yl)-3,8-diaza-bicyclo[4.2.0]octane | CHEMBL269047 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H17N3O |
|---|
| Mol. Mass. | 219.2829 |
|---|
| SMILES | COc1cncc(c1)N1CC[C@H]2CN[C@H]2C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
