| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-K receptor |
|---|
| Ligand | BDBM50412943 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_515484 (CHEMBL992211) |
|---|
| Ki | 2±n/a nM |
|---|
| Citation |  Smith, PW; Wyman, PA; Lovell, P; Goodacre, C; Serafinowska, HT; Vong, A; Harrington, F; Flynn, S; Bradley, DM; Porter, R; Coggon, S; Murkitt, G; Searle, K; Thomas, DR; Watson, JM; Martin, W; Wu, Z; Dawson, LA New quinoline NK3 receptor antagonists with CNS activity. Bioorg Med Chem Lett19:837-40 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-K receptor |
|---|
| Name: | Neuromedin-K receptor |
|---|
| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52221.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29371 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
|
|
|
|---|
| BDBM50412943 |
|---|
| n/a |
|---|
| Name | BDBM50412943 |
|---|
| Synonyms: | CHEMBL480818 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23N3O |
|---|
| Mol. Mass. | 381.4696 |
|---|
| SMILES | CC[C@H](NC(=O)c1c(N)c(nc2ccccc12)-c1ccccc1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
