| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50414306 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_574385 (CHEMBL1028693) |
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| IC50 | 1±n/a nM |
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| Citation |  Guile, SD; Alcaraz, L; Birkinshaw, TN; Bowers, KC; Ebden, MR; Furber, M; Stocks, MJ Antagonists of the P2X(7) receptor. From lead identification to drug development. J Med Chem52:3123-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM50414306 |
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| n/a |
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| Name | BDBM50414306 |
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| Synonyms: | CHEMBL556680 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33N3O2 |
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| Mol. Mass. | 419.5591 |
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| SMILES | O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2c1ccn(CC1CCCN1)c2=O |TLB:4:3:6.5.10:8,10:5:12:9.8.11,10:9:12:6.5.4,2:3:6.5.10:8,THB:4:5:8:12.3.11,2:3:6:10.9.8,11:3:6:10.9.8,11:9:6:12.4.3| |
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| Structure | 
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