| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50216402 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_574503 (CHEMBL1030342) |
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| IC50 | 19.95±n/a nM |
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| Citation |  Guile, SD; Alcaraz, L; Birkinshaw, TN; Bowers, KC; Ebden, MR; Furber, M; Stocks, MJ Antagonists of the P2X(7) receptor. From lead identification to drug development. J Med Chem52:3123-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM50216402 |
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| n/a |
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| Name | BDBM50216402 |
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| Synonyms: | CHEMBL230925 | N-(2-(4-(4-nitrophenyl)piperazin-1-yl)-2-oxoethyl)isoquinoline-5-sulfonamide | isoquinolinesulfon-5-yl-{2-[4-(4-nitrophenyl)piperazin-1-yl]-2-oxoethyl}amide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O5S |
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| Mol. Mass. | 455.487 |
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| SMILES | [O-][N+](=O)c1ccc(cc1)N1CCN(CC1)C(=O)CNS(=O)(=O)c1cccc2cnccc12 |
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| Structure | 
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