| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50415265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_604256 (CHEMBL1050401) |
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| Ki | 31.6±n/a nM |
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| Citation |  Sabbatini, FM; Di Fabio, R; Griffante, C; Pentassuglia, G; Zonzini, L; Melotto, S; Alvaro, G; Capelli, AM; Pippo, L; Perdona', E; St Denis, Y; Costa, S; Corsi, M Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists. Bioorg Med Chem Lett20:623-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50415265 |
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| n/a |
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| Name | BDBM50415265 |
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| Synonyms: | CHEMBL591075 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26F7N3O |
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| Mol. Mass. | 517.4823 |
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| SMILES | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r| |
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| Structure | 
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