Reaction Details |
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Target | P2X purinoceptor 3 |
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Ligand | BDBM50415550 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_612711 (CHEMBL1069583) |
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IC50 | 100±n/a nM |
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Citation | Brotherton-Pleiss, CE; Dillon, MP; Ford, AP; Gever, JR; Carter, DS; Gleason, SK; Lin, CJ; Moore, AG; Thompson, AW; Villa, M; Zhai, Y Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett20:1031-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 3 |
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Name: | P2X purinoceptor 3 |
Synonyms: | ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44397.63 |
Organism: | RAT |
Description: | Purinergic, P2X3 0 RAT::P49654 |
Residue: | 397 |
Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
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BDBM50415550 |
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n/a |
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Name | BDBM50415550 |
Synonyms: | CHEMBL599760 | Ro-85 |
Type | Small organic molecule |
Emp. Form. | C22H27N5O2S |
Mol. Mass. | 425.547 |
SMILES | C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 |r| |
Structure |
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