| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 2 |
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| Ligand | BDBM50415563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_612723 (CHEMBL1069595) |
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| IC50 | >10000±n/a nM |
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| Citation |  Brotherton-Pleiss, CE; Dillon, MP; Ford, AP; Gever, JR; Carter, DS; Gleason, SK; Lin, CJ; Moore, AG; Thompson, AW; Villa, M; Zhai, Y Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett20:1031-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 2 |
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| Name: | P2X purinoceptor 2 |
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| Synonyms: | ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51765.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PurinergicP2X2/3 0 HUMAN::Q9UBL9 |
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| Residue: | 471 |
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| Sequence: | MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
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| BDBM50415563 |
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| n/a |
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| Name | BDBM50415563 |
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| Synonyms: | CHEMBL605325 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N6O2 |
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| Mol. Mass. | 434.534 |
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| SMILES | CCCc1nc(oc1C(=O)NC(C)CN1CCN(CC1)c1ncccn1)-c1ccccc1 |
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| Structure | 
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