| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 3 |
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| Ligand | BDBM50415581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_612711 (CHEMBL1069583) |
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| IC50 | 1258.93±n/a nM |
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| Citation |  Brotherton-Pleiss, CE; Dillon, MP; Ford, AP; Gever, JR; Carter, DS; Gleason, SK; Lin, CJ; Moore, AG; Thompson, AW; Villa, M; Zhai, Y Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett20:1031-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 3 |
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| Name: | P2X purinoceptor 3 |
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| Synonyms: | ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44397.63 |
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| Organism: | RAT |
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| Description: | Purinergic, P2X3 0 RAT::P49654 |
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| Residue: | 397 |
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| Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
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| BDBM50415581 |
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| n/a |
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| Name | BDBM50415581 |
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| Synonyms: | CHEMBL597316 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N7O |
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| Mol. Mass. | 467.5655 |
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| SMILES | CC(CN1CCN(CC1)c1ncccn1)NC(=O)c1cc(-c2ccccc2)n(n1)-c1ccccc1 |
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| Structure | 
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