| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
|---|
| Ligand | BDBM50415826 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_625546 (CHEMBL1109726) |
|---|
| IC50 | 398±n/a nM |
|---|
| Citation |  Zuercher, WJ; Buckholz, RG; Campobasso, N; Collins, JL; Galardi, CM; Gampe, RT; Hyatt, SM; Merrihew, SL; Moore, JT; Oplinger, JA; Reid, PR; Spearing, PK; Stanley, TB; Stewart, EL; Willson, TM Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem53:3412-6 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Oxysterols receptor LXR-beta |
|---|
| Name: | Oxysterols receptor LXR-beta |
|---|
| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 50978.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P55055 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
|
|
|
|---|
| BDBM50415826 |
|---|
| n/a |
|---|
| Name | BDBM50415826 |
|---|
| Synonyms: | CHEMBL1090238 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H32FN3O2S |
|---|
| Mol. Mass. | 529.668 |
|---|
| SMILES | Fc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)Cc1ccc(cc1)-c1cccc(CN2CCNCC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
