Reaction Details |
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Target | Serine/threonine-protein kinase TBK1 |
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Ligand | BDBM50418165 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_741024 (CHEMBL1764210) |
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IC50 | >3162.28±n/a nM |
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Citation | Miller, DD; Bamborough, P; Christopher, JA; Baldwin, IR; Champigny, AC; Cutler, GJ; Kerns, JK; Longstaff, T; Mellor, GW; Morey, JV; Morse, MA; Nie, H; Rumsey, WL; Taggart, JJ 3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-ß. Bioorg Med Chem Lett21:2255-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase TBK1 |
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Name: | Serine/threonine-protein kinase TBK1 |
Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
Type: | protein |
Mol. Mass.: | 83645.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9UHD2 |
Residue: | 729 |
Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
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BDBM50418165 |
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n/a |
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Name | BDBM50418165 |
Synonyms: | CHEMBL1761512 |
Type | Small organic molecule |
Emp. Form. | C23H27N3O3S |
Mol. Mass. | 425.544 |
SMILES | CCCS(=O)(=O)N1CCC(CC1)c1c[nH]c2c(cc(cc12)-c1ccccc1)C(N)=O |
Structure |
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