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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 5 subunit alpha | ||
| Ligand | BDBM50418797 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_753413 (CHEMBL1799748) | ||
| IC50 | 2630.27±n/a nM | ||
| Citation |  Macsari, I; Sandberg, L; Besidski, Y; Gravenfors, Y; Ginman, T; Bylund, J; Bueters, T; Eriksson, AB; Lund, PE; Venyike, E; Arvidsson, PI Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship. Bioorg Med Chem Lett21:3871-6 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 5 subunit alpha | |||
| Name: | Sodium channel protein type 5 subunit alpha | ||
| Synonyms: | HH1 | SCN5A | SCN5A_HUMAN | Sodium channel alpha subunit | Sodium channel protein type 5 subunit alpha/beta-1/beta-2 | Sodium channel protein type V alpha subunit | Voltage-gated sodium channel subunit alpha Nav1.5 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 226908.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14524 | ||
| Residue: | 2016 | ||
| Sequence: |
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| BDBM50418797 | |||
| n/a | |||
| Name | BDBM50418797 | ||
| Synonyms: | CHEMBL1797389 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H12Cl4N2O3 | ||
| Mol. Mass. | 446.111 | ||
| SMILES | Cc1onc(c1NC(=O)OCc1cc(Cl)ccc1Cl)-c1c(Cl)cccc1Cl |(-5.13,-5.07,;-6.03,-6.32,;-7.57,-6.33,;-8.04,-7.79,;-6.79,-8.7,;-5.55,-7.79,;-4.08,-8.26,;-2.76,-7.46,;-2.79,-5.92,;-1.41,-8.21,;-.09,-7.41,;1.25,-8.16,;1.27,-9.7,;2.62,-10.45,;2.64,-11.99,;3.94,-9.65,;3.91,-8.1,;2.56,-7.37,;2.52,-5.83,;-6.79,-10.24,;-8.11,-11.01,;-9.45,-10.24,;-8.12,-12.56,;-6.78,-13.33,;-5.45,-12.56,;-5.45,-11.01,;-4.12,-10.23,)| | ||
| Structure | 
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