Reaction Details |
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Target | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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Ligand | BDBM50419071 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_767270 (CHEMBL1825382) |
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IC50 | 15848.93±n/a nM |
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Citation | McClure, KJ; Maher, M; Wu, N; Chaplan, SR; Eckert, WA; Lee, DH; Wickenden, AD; Hermann, M; Allison, B; Hawryluk, N; Breitenbucher, JG; Grice, CA Discovery of a novel series of selective HCN1 blockers. Bioorg Med Chem Lett21:5197-201 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
Synonyms: | BCNG-1 | BCNG1 | Brain cyclic nucleotide-gated channel 1 | HCN1 | HCN1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 98811.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_767270 |
Residue: | 890 |
Sequence: | MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFK
VDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAV
EKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN
LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIG
YGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSF
HKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANAD
PNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGE
ICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI
LLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRM
RTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYA
SPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLT
REVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVT
LFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL
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BDBM50419071 |
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n/a |
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Name | BDBM50419071 |
Synonyms: | CHEMBL1823883 |
Type | Small organic molecule |
Emp. Form. | C21H32N2O2 |
Mol. Mass. | 344.491 |
SMILES | CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCCCC1 |
Structure |
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