| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
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| Ligand | BDBM50419053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_767271 (CHEMBL1825383) |
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| IC50 | 31.62±n/a nM |
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| Citation |  McClure, KJ; Maher, M; Wu, N; Chaplan, SR; Eckert, WA; Lee, DH; Wickenden, AD; Hermann, M; Allison, B; Hawryluk, N; Breitenbucher, JG; Grice, CA Discovery of a novel series of selective HCN1 blockers. Bioorg Med Chem Lett21:5197-201 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
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| Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
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| Synonyms: | HCN4 | HCN4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 129069.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454251 |
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| Residue: | 1203 |
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| Sequence: | MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSA
AAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHG
HLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCE
QPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAV
EREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNV
VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE
TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN
LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIG
YGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSF
HKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD
PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE
ICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSI
LLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQA
PLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA
SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVA
ATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLP
PPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFT
PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT
QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR
PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLP
SNL
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| BDBM50419053 |
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| n/a |
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| Name | BDBM50419053 |
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| Synonyms: | CHEMBL2052019 | ZD-7288 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H21N4 |
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| Mol. Mass. | 257.3535 |
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| SMILES | CC\[N+](c1ccccc1)=c1/cc(NC)n(C)c(C)n1 |
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| Structure | 
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