Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M3 | ||
| Ligand | BDBM50419538 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789189 (CHEMBL1924273) | ||
| IC50 | 0.0631±n/a nM | ||
| Citation |  Mete, A; Bowers, K; Chevalier, E; Donald, DK; Edwards, H; Escott, KJ; Ford, R; Grime, K; Millichip, I; Teobald, B; Russell, V The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorg Med Chem Lett21:7440-6 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M3 | |||
| Name: | Muscarinic acetylcholine receptor M3 | ||
| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 66151.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20309 | ||
| Residue: | 590 | ||
| Sequence: |
| ||
| BDBM50419538 | |||
| n/a | |||
| Name | BDBM50419538 | ||
| Synonyms: | CHEMBL1921935 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H39N2O3S | ||
| Mol. Mass. | 483.685 | ||
| SMILES | C[C@@](N1CCCCC1)(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)c1cccs1 |r,wU:1.0,wD:1.8,11.11,(41.55,-11.62,;41.56,-10.08,;41.55,-8.53,;42.89,-7.77,;42.89,-6.23,;41.55,-5.45,;40.21,-6.23,;40.21,-7.78,;42.9,-10.85,;42.9,-12.4,;44.24,-10.07,;45.58,-10.85,;45.58,-12.39,;46.92,-13.15,;46.96,-14.69,;48.31,-15.42,;49.62,-14.61,;50.98,-15.34,;52.29,-14.53,;53.64,-15.27,;54.94,-14.46,;54.9,-12.92,;53.54,-12.19,;52.23,-13,;48.25,-12.39,;48.25,-10.85,;46.92,-10.06,;46.13,-11.39,;47.62,-11.79,;40.32,-10.99,;38.84,-10.53,;37.95,-11.79,;38.86,-13.02,;40.32,-12.54,)| | ||
| Structure | 
| ||