Ki Summary

Reaction Details

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Target

Solute carrier organic anion transporter family member 1B1

Ligand

BDBM18375

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_838505 (CHEMBL2078133)

IC50

3600±n/a nM

Citation

Chen, C; Mireles, RJ; Campbell, SD; Lin, J; Mills, JB; Xu, JJ; Smolarek, TA Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos33:537-46 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Solute carrier organic anion transporter family member 1B1

Name:

Solute carrier organic anion transporter family member 1B1

Synonyms:

Type:

Protein

Mol. Mass.:

76468.06

Organism:

Homo sapiens (Human)

Description:

Q9Y6L6

Residue:

691

Sequence:

MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFE
ISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGY
YRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNML
RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV
DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLE
TNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVF
KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS
FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT
YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI
QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI
KWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASE
NGSVMDEANLESLNKNKHFVPSAGADSETHC

BDBM18375

n/a

Name

BDBM18375

Synonyms:

(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid | Simvastatin | Simvastatin acid

Type

Small organic molecule

Emp. Form.

C25H40O6

Mol. Mass.

436.5815

SMILES

[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)C(C)(C)CC |r,c:6,9|

Structure