Reaction Details |
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Target | Casein kinase I isoform epsilon |
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Ligand | BDBM50364141 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_842117 (CHEMBL2091534) |
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IC50 | 130±n/a nM |
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Citation | Yang, LL; Li, GB; Yan, HX; Sun, QZ; Ma, S; Ji, P; Wang, ZR; Feng, S; Zou, J; Yang, SY Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. Eur J Med Chem56:30-38 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Casein kinase I isoform epsilon |
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Name: | Casein kinase I isoform epsilon |
Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
Type: | Protein |
Mol. Mass.: | 47340.25 |
Organism: | Homo sapiens (Human) |
Description: | P49674 |
Residue: | 416 |
Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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BDBM50364141 |
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n/a |
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Name | BDBM50364141 |
Synonyms: | CHEMBL1951415 |
Type | Small organic molecule |
Emp. Form. | C19H20FN5 |
Mol. Mass. | 337.394 |
SMILES | Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1 |
Structure |
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