| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM22879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_84246 |
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| Kd | 380±n/a nM |
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| Citation |  Zhang, M; ter Laak, AM; Timmerman, H Optical isomers of the H1 antihistamine terfenadine: synthesis and activity Bioorg Med Chem Lett1:387-390 (1991) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM22879 |
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| n/a |
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| Name | BDBM22879 |
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| Synonyms: | (1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol | (1R)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol | (R)-(+)-Terfenadine | Terfenadine | cid_5405 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41NO2 |
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| Mol. Mass. | 471.6734 |
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| SMILES | CC(C)(C)c1ccc(cc1)[C@H](O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1 |
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| Structure | 
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