| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
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| Ligand | BDBM82505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_77009 (CHEMBL696086) |
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| IC50 | 0.10±n/a nM |
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| Citation |  Gaster, LM; Jennings, AJ; Joiner, GF; King, FD; Mulholland, KR; Rahman, SK; Starr, S; Wyman, PA; Wardle, KA; Ellis, ES (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide. J Med Chem36:4121-3 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 4 |
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| Name: | 5-hydroxytryptamine receptor 4 |
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| Synonyms: | 5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43735.29 |
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| Organism: | GUINEA PIG |
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| Description: | 5-HT4 HTR4 GUINEA PIG::O70528 |
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| Residue: | 388 |
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| Sequence: | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
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| BDBM82505 |
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| n/a |
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| Name | BDBM82505 |
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| Synonyms: | CAS_121881 | NSC_121881 | SB204070 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27ClN2O4 |
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| Mol. Mass. | 382.882 |
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| SMILES | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1 |
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| Structure | 
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