Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM50135841 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_194806 (CHEMBL799889) |
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IC50 | 347±n/a nM |
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Citation | Kotsikorou, E; Oldfield, E A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. J Med Chem46:2932-44 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM50135841 |
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n/a |
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Name | BDBM50135841 |
Synonyms: | (4-methylthiazol-2-ylamino)methylenediphosphonic acid | (Bis-phosphono-methyl)-(4-methyl-thiazol-2-yl)-ammonium | CHEMBL293116 | [(4-Methyl-thiazol-2-ylamino)-phosphono-methyl]-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C5H10N2O6P2S |
Mol. Mass. | 288.155 |
SMILES | Cc1csc(NC(P(O)(O)=O)P(O)(O)=O)n1 |
Structure |
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