| Reaction Details |
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 | Report a problem with these data |
| Target | TRAF2 and NCK-interacting protein kinase |
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| Ligand | BDBM50424536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_933616 (CHEMBL2320000) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Ho, KK; Parnell, KM; Yuan, Y; Xu, Y; Kultgen, SG; Hamblin, S; Hendrickson, TF; Luo, B; Foulks, JM; McCullar, MV; Kanner, SB Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett23:569-73 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TRAF2 and NCK-interacting protein kinase |
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| Name: | TRAF2 and NCK-interacting protein kinase |
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| Synonyms: | KIAA0551 | TNIK | TNIK_HUMAN | TRAF2 and NCK-interacting protein kinase (TNIK) | TRAF2- and NCK-interacting kinase |
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| Type: | Protein |
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| Mol. Mass.: | 154954.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UKE5 |
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| Residue: | 1360 |
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| Sequence: | MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
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| BDBM50424536 |
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| n/a |
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| Name | BDBM50424536 |
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| Synonyms: | CHEMBL2312143 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N5O |
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| Mol. Mass. | 399.4882 |
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| SMILES | COc1ccc(cc1-c1ccnc(Nc2ccc(cc2)N2CCN(C)CC2)c1)C#N |
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| Structure | 
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