| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
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| Ligand | BDBM50425477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_935778 (CHEMBL2317358) |
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| IC50 | >10000±n/a nM |
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| Citation |  Rivara, S; Piersanti, G; Bartoccini, F; Diamantini, G; Pala, D; Riccioni, T; Stasi, MA; Cabri, W; Borsini, F; Mor, M; Tarzia, G; Minetti, P Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors. J Med Chem56:1247-61 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A |
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| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) |
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| Type: | Protein |
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| Mol. Mass.: | 59689.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21397 |
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| Residue: | 527 |
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| Sequence: | MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
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| BDBM50425477 |
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| n/a |
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| Name | BDBM50425477 |
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| Synonyms: | (E)-8-(4-Chlorostyryl)caffeine (4a) | CHEMBL2313284 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15ClN4O2 |
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| Mol. Mass. | 330.769 |
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| SMILES | Cn1c(\C=C\c2ccc(Cl)cc2)nc2n(C)c(=O)n(C)c(=O)c12 |
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| Structure | 
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