Reaction Details |
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Target | Muscarinic acetylcholine receptor M2 |
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Ligand | BDBM50111346 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_936427 (CHEMBL2317636) |
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Ki | 0.890000±n/a nM |
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Citation | Zheng, G; Smith, AM; Huang, X; Subramanian, KL; Siripurapu, KB; Deaciuc, A; Zhan, CG; Dwoskin, LP Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists. J Med Chem56:1693-703 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M2 |
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Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
Type: | GPCR |
Mol. Mass.: | 51730.61 |
Organism: | Homo sapiens (Human) |
Description: | P08172 |
Residue: | 466 |
Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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BDBM50111346 |
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n/a |
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Name | BDBM50111346 |
Synonyms: | (2-Amino-3-methyl-phenyl)-{4-[4-(3-chloro-benzenesulfonyl)-benzyl]-[1,4']bipiperidinyl-1'-yl}-methanone | CHEMBL12098 | SCH-211803 |
Type | Small organic molecule |
Emp. Form. | C31H36ClN3O3S |
Mol. Mass. | 566.154 |
SMILES | Cc1cccc(C(=O)N2CCC(CC2)N2CCC(Cc3ccc(cc3)S(=O)(=O)c3cccc(Cl)c3)CC2)c1N |
Structure |
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