Ki Summary

Reaction Details

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Target

Excitatory amino acid transporter 3

Ligand

BDBM50426290

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_936435 (CHEMBL2317644)

IC50

>1000000±n/a nM

Citation

Assaf, Z; Larsen, AP; Venskutonyte, R; Han, L; Abrahamsen, B; Nielsen, B; Gajhede, M; Kastrup, JS; Jensen, AA; Pickering, DS; Frydenvang, K; Gefflaut, T; Bunch, L Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. J Med Chem56:1614-28 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Excitatory amino acid transporter 3

Name:

Excitatory amino acid transporter 3

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57096.71

Organism:

Homo sapiens (Human)

Description:

Excitatory Amino Acid EAAT3 0 HUMAN::P43005

Residue:

524

Sequence:

MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILM
RMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMT
EESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF
NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF

BDBM50426290

n/a

Name

BDBM50426290

Synonyms:

CHEMBL2312682

Type

Small organic molecule

Emp. Form.

C8H12N2O4

Mol. Mass.

200.1919

SMILES

N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O |r|

Structure