| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C zeta type |
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| Ligand | BDBM50427363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941098 (CHEMBL2330895) |
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| Ki | >5000±n/a nM |
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| Citation |  Jimenez, JM; Boyall, D; Brenchley, G; Collier, PN; Davis, CJ; Fraysse, D; Keily, SB; Henderson, J; Miller, A; Pierard, F; Settimo, L; Twin, HC; Bolton, CM; Curnock, AP; Chiu, P; Tanner, AJ; Young, S Design and optimization of selective protein kinase C¿ (PKC¿) inhibitors for the treatment of autoimmune diseases. J Med Chem56:1799-810 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C zeta type |
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| Name: | Protein kinase C zeta type |
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| Synonyms: | KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta |
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| Type: | Enzyme |
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| Mol. Mass.: | 67649.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 592 |
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| Sequence: | MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
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| BDBM50427363 |
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| n/a |
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| Name | BDBM50427363 |
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| Synonyms: | CHEMBL2326002 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24ClFN6O |
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| Mol. Mass. | 418.896 |
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| SMILES | CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl |r| |
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| Structure | 
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