Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM50427811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_940709 (CHEMBL2330000) |
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IC50 | 1.8±n/a nM |
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Citation | Aguilar, A; Zhou, H; Chen, J; Liu, L; Bai, L; McEachern, D; Yang, CY; Meagher, J; Stuckey, J; Wang, S A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem56:3048-67 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM50427811 |
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n/a |
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Name | BDBM50427811 |
Synonyms: | BM-1074 | CHEMBL2325764 |
Type | Small organic molecule |
Emp. Form. | C50H57ClN8O7S3 |
Mol. Mass. | 1013.685 |
SMILES | CC(C)n1c(C)c(C(=O)NS(C)(=O)=O)c(c1-c1ccc(Cl)cc1)-c1cccc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN(C)C)CSc3ccccc3)c(c2)[N+]([O-])=O)cc1 |r| |
Structure |
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