| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-B receptor 3 |
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| Ligand | BDBM50428059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941276 (CHEMBL2329866) |
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| IC50 | 4400±n/a nM |
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| Citation |  Incerti, M; Tognolini, M; Russo, S; Pala, D; Giorgio, C; Hassan-Mohamed, I; Noberini, R; Pasquale, EB; Vicini, P; Piersanti, S; Rivara, S; Barocelli, E; Mor, M; Lodola, A Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem56:2936-47 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-B receptor 3 |
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| Name: | Ephrin type-B receptor 3 |
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| Synonyms: | EPHB3 | EPHB3_HUMAN | ETK2 | Ephrin receptor | Ephrin type-B receptor 3 | Ephrin type-B receptor 3 (EPHB3) | HEK2 | TYRO6 | Tyrosine Kinase EPHB3 |
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| Type: | Protein |
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| Mol. Mass.: | 110326.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54753 |
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| Residue: | 998 |
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| Sequence: | MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMDTKWVTSELAWTSHPES
GWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIP
NIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRS
FGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGT
CIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGSYKAKQGEGP
CLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWS
EPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTR
YTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPN
GVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEF
ETTSERGSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQY
IAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREV
FVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALD
SFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLS
RFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYW
DMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAA
SLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQM
TAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV
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| BDBM50428059 |
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| n/a |
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| Name | BDBM50428059 |
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| Synonyms: | CHEMBL2322989 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H50N2O4 |
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| Mol. Mass. | 562.7825 |
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| SMILES | C[C@H](CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r| |
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| Structure | 
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