Reaction Details |
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Target | Telomerase reverse transcriptase |
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Ligand | BDBM50428823 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_943537 (CHEMBL2342918) |
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IC50 | >10000±n/a nM |
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Citation | Chen, CL; Chang, DM; Chen, TC; Lee, CC; Hsieh, HH; Huang, FC; Huang, KF; Guh, JH; Lin, JJ; Huang, HS Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology. Eur J Med Chem60:29-41 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Telomerase reverse transcriptase |
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Name: | Telomerase reverse transcriptase |
Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
Type: | PROTEIN |
Mol. Mass.: | 127099.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1447029 |
Residue: | 1132 |
Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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BDBM50428823 |
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n/a |
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Name | BDBM50428823 |
Synonyms: | CHEMBL2336666 | NSC-749235 |
Type | Small organic molecule |
Emp. Form. | C21H20N4O2 |
Mol. Mass. | 360.4091 |
SMILES | CN1CCN(Cc2nc3ccc4C(=O)c5ccccc5C(=O)c4c3[nH]2)CC1 |
Structure |
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