Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-1 |
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Ligand | BDBM50428991 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_948493 (CHEMBL2343194) |
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EC50 | 4400±n/a nM |
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Citation | Wu, J; Zhang, D; Chen, L; Li, J; Wang, J; Ning, C; Yu, N; Zhao, F; Chen, D; Chen, X; Chen, K; Jiang, H; Liu, H; Liu, D Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. J Med Chem56:761-80 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-1 |
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Name: | NAD-dependent protein deacetylase sirtuin-1 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
Type: | Developmental protein; hydrolase |
Mol. Mass.: | 81626.66 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 747 |
Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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BDBM50428991 |
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n/a |
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Name | BDBM50428991 |
Synonyms: | CHEMBL2333663 |
Type | Small organic molecule |
Emp. Form. | C19H11Br2N3O3 |
Mol. Mass. | 489.117 |
SMILES | Oc1c(Br)cc(\C=N\NC(=O)c2ccc3cc(ccc3c2)C#N)c(O)c1Br |
Structure |
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