| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heat shock protein HSP 90-alpha |
|---|
| Ligand | BDBM50429452 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_943216 (CHEMBL2338980) |
|---|
| Kd | 73±n/a nM |
|---|
| Citation |  Dal Piaz, F; Vassallo, A; Temraz, A; Cotugno, R; Belisario, MA; Bifulco, G; Chini, MG; Pisano, C; De Tommasi, N; Braca, A A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors. J Med Chem56:1583-95 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heat shock protein HSP 90-alpha |
|---|
| Name: | Heat shock protein HSP 90-alpha |
|---|
| Synonyms: | HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 |
|---|
| Type: | Molecular Chaperone |
|---|
| Mol. Mass.: | 84623.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07900 |
|---|
| Residue: | 732 |
|---|
| Sequence: | MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
GDDDTSRMEEVD
|
|
|
|---|
| BDBM50429452 |
|---|
| n/a |
|---|
| Name | BDBM50429452 |
|---|
| Synonyms: | CHEMBL2332361 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H30O12 |
|---|
| Mol. Mass. | 510.4878 |
|---|
| SMILES | OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@H]3[C@@H](C[C@@](O)(CO)[C@@H]23)OC(=O)\C=C/c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r,c:8| |
|---|
| Structure | 
|
|---|
Search and Browse
