Reaction Details |
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Target | Serine/threonine-protein kinase PAK 2 |
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Ligand | BDBM50429477 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_943655 (CHEMBL2344386) |
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IC50 | >10000±n/a nM |
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Citation | Yang, LL; Li, GB; Ma, S; Zou, C; Zhou, S; Sun, QZ; Cheng, C; Chen, X; Wang, LJ; Feng, S; Li, LL; Yang, SY Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo. J Med Chem56:1641-55 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PAK 2 |
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Name: | Serine/threonine-protein kinase PAK 2 |
Synonyms: | PAK2 | PAK2_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | Serine/threonine-protein kinase PAK 2 | Serine/threonine-protein kinase PAK 2 (PAK2) | p21-Activated kinase 2 (PAK2) |
Type: | Enzyme |
Mol. Mass.: | 58037.40 |
Organism: | Homo sapiens (Human) |
Description: | Q13177 |
Residue: | 524 |
Sequence: | MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGT
EKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNP
QAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAP
PVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIV
SIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKE
LKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLH
ANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY
GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRC
LEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
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BDBM50429477 |
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n/a |
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Name | BDBM50429477 |
Synonyms: | CHEMBL2332840 |
Type | Small organic molecule |
Emp. Form. | C19H12ClF3N6O2 |
Mol. Mass. | 448.786 |
SMILES | FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)ccc1Cl |
Structure |
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