Reaction Details |
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Target | Sterol O-acyltransferase 2 |
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Ligand | BDBM50429597 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_945256 (CHEMBL2339988) |
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IC50 | 2.7±n/a nM |
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Citation | Ohtawa, M; Yamazaki, H; Ohte, S; Matsuda, D; Ohshiro, T; Rudel, LL; Omura, S; Tomoda, H; Nagamitsu, T Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1. Bioorg Med Chem Lett23:1285-7 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 2 |
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Name: | Sterol O-acyltransferase 2 |
Synonyms: | ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 59912.75 |
Organism: | Homo sapiens (Human) |
Description: | O75908 |
Residue: | 522 |
Sequence: | MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
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BDBM50429597 |
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n/a |
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Name | BDBM50429597 |
Synonyms: | CHEMBL2333812 |
Type | Small organic molecule |
Emp. Form. | C37H41NO10S |
Mol. Mass. | 691.787 |
SMILES | CSc1ccc(cc1)C(=O)O[C@H]1C[C@H]2[C@](C)(COC(C)=O)[C@H](CC[C@]2(C)[C@H]2[C@@H](O)c3c(O[C@]12C)cc(oc3=O)-c1cccnc1)OC(C)=O |r| |
Structure |
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