Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase 14 |
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Ligand | BDBM50429618 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_945747 (CHEMBL2346384) |
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IC50 | 24000±n/a nM |
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Citation | Li, K; McGee, LR; Fisher, B; Sudom, A; Liu, J; Rubenstein, SM; Anwer, MK; Cushing, TD; Shin, Y; Ayres, M; Lee, F; Eksterowicz, J; Faulder, P; Waszkowycz, B; Plotnikova, O; Farrelly, E; Xiao, SH; Chen, G; Wang, Z Inhibiting NF-¿B-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg Med Chem Lett23:1238-44 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase 14 |
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Name: | Mitogen-activated protein kinase kinase kinase 14 |
Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK |
Type: | Protein |
Mol. Mass.: | 104059.50 |
Organism: | Homo sapiens (Human) |
Description: | Q99558 |
Residue: | 947 |
Sequence: | MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
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BDBM50429618 |
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n/a |
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Name | BDBM50429618 |
Synonyms: | CHEMBL2334587 |
Type | Small organic molecule |
Emp. Form. | C23H22N4O |
Mol. Mass. | 370.447 |
SMILES | CC(O)c1ccc(cc1)-c1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1 |
Structure |
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