| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50430472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_945360 (CHEMBL2341486) |
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| IC50 | 33170±n/a nM |
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| Citation |  Lee, K; Cho, SH; Lee, JH; Goo, J; Lee, SY; Boovanahalli, SK; Yeo, SK; Lee, SJ; Kim, YK; Kim, DH; Choi, Y; Song, GY Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors. Eur J Med Chem62:515-25 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT |
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| Type: | Multi-pass membrane protein may form homo- or heterodimers. |
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| Mol. Mass.: | 64751.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35610 |
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| Residue: | 550 |
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| Sequence: | MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
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| BDBM50430472 |
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| n/a |
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| Name | BDBM50430472 |
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| Synonyms: | CHEMBL2335546 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14O3S |
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| Mol. Mass. | 262.324 |
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| SMILES | CCC=CS(=O)c1cc(O)c2ccccc2c1O |w:3.3| |
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| Structure | 
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