Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50430878 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_945907 (CHEMBL2340521) |
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Ki | 0.27±n/a nM |
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Citation | Tang, D; McKinley, ET; Hight, MR; Uddin, MI; Harp, JM; Fu, A; Nickels, ML; Buck, JR; Manning, HC Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. J Med Chem56:3429-33 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50430878 |
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n/a |
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Name | BDBM50430878 |
Synonyms: | CHEMBL2336474 |
Type | Small organic molecule |
Emp. Form. | C24H31FN4O2 |
Mol. Mass. | 426.5269 |
SMILES | CCN(CC)C(=O)Cc1c(nn2c(CC)cc(CC)nc12)-c1ccc(OCCF)cc1 |
Structure |
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